Opioid Peptide Library

	Catalog #	Size	Price
	L-002	58 peptides	$2542

Contents:	96 well plate(s), where each well contains 1.5 nmol of peptide packaged in 15µg of BSA. (Please inquire for larger peptide quantity)
List of Peptides:	Download(PDF)

	Peptide Name	Catelog No.	M.W.
1	Dynorphin, big (Human, Rat, Mouse, Porcine)	021-01	3982.26
2	Dynorphin A (Human, Rat, Mouse, Porcine)	021-03	2147.51
3	Dynorphin A (1-6) / Endorphin (1-6), alpha-Neo / Leu-Enkephalin-Arg (Human, Rat, Mouse, Porcine)	021-08	711.38
4	Dynorphin A (1-13) (Human, Rat, Mouse, Porcine)	021-21	1602.99
5	Dynorphin A (2-13) amide (Human, Rat, Mouse, Porcine)	021-24	1439.82
6	Dynorphin A (2-17) (Human, Rat, Mouse, Porcine)	021-30	1983.14
7	Dynorphin B / Rimorphin (Human, Rat, Mouse, Porcine)	021-37	1570.86
8	Endorphin, alpha-Neo (Porcine)	021-40	1228.46
9	Endorphin, beta-neo	021-44	1099.59
10	Orphanin FQ / Nociceptin (Human, Rat, Mouse, Ox)	021-55	1809.06
11	pro-Orphanin FQ (85-119) / pro-Nociceptin (85-119) / Nocistatin-35 (Rat)	021-58	3907.25
12	pro-Orphanin FQ (141-157) / pro-Nociceptin (141-157)	021-59	2081.4
13	[Phe-psi-Gly]-Orphanin FQ (1-13) amide / [Phe-psi-Gly]-Nociceptin (1-13) amide (Human, Rat, Mouse, Ox)	021-70	1376.6
14	Orphanin FQ (1-13) amide / Nociceptin (1-13) amide (Human, Rat, Mouse, Ox)	021-71	1381.6
15	prepro-Orphanin FQ (111-127) / Nocistatin / PNP-3 (Bovine)	021-75	1927.1
16	prepro-Orphanin FQ (98-127) / Nocistatin-30 (Human)	021-78	3561.98
17	PNP-3-8P (Bovine)	021-80	1015.13
18	PNP-2/3 / Nocistatin-41 (Mouse)	021-81	4375.71
19	prepro-Orphanin FQ (154-181), free acid (Rat) / prepro-Orphanin FQ (160-187) free acid (Mouse)	021-85	3413.89
20	pro-Enkephalin A (104-129) amide / Amidorphin (Bovine)	024-04	2947.32
21	BAM-18P (Bovine)	024-06	2333.07
22	BAM-22P (Bovine)	024-07	2837.35
23	CTOP amide (Cys2, Tyr3, Orn5, Pen7) / Somatostatin Analog	024-08	1061.59
24	CTAP amide (Cys2, Tyr3, Arg5, Pen7)	024-09	1104.3
25	[D-Ala2, N-Me-Phe4, Gly-ol]-Enkephalin / DAMGO / DAGO	024-10	513.26
26	[D-Ala2, D-Leu5]-Enkephalin	024-11	569.29
27	[D-Pen2, D-Pen5]-Enkephalin	024-12	645.57
28	Leu-Enkephalin	024-21	555.63
29	[D-Ser2]-Leu-Enkephalin-Thr / Delta-Receptor Peptide / DSLET	024-33	686.34
30	[D-Thr2]-Leu-Enkephalin-Thr / DTLET	024-34	700.35
31	Met-Enkephalin	024-35	573.24
32	[Des-Tyr1]-Met-Enkephalin	024-45	410.5
33	Met-Enkephalin-Arg	024-46	729.34
34	Met-Enkephalin-Arg-Phe	024-50	876.4
35	Metorphinamide / Adrenorphin	024-54	983.5
36	Peptide E / 3200-Dalton Adrenal Enkephalin-Containing Peptide (Bovine)	024-57	3154.53
37	Thiorphan / D,L-3-mercapto-2-benzylpropanoyl-Glycine	024-59	254
38	Spinorphin (Bovine)	024-63	877.06
39	Kyotorphin	037-01	337.01
40	Casomorphin (1-4), amide beta / Morphiceptin	044-06	521.25
41	[N-MePhe, D-Pro4]-Morphiceptin / PL017	044-08	535.28
42	Endomorphin-1	044-10	610.71
43	Endomorphin-2	044-11	571.68
44	Dermenkephalin / Deltrophin (Phyllomedusa sauvageii)	050-04	954.39
45	[D-Ala2]-Deltorphin I	050-05	768.36
46	[D-Ala2]-Deltorphin II	050-06	782.38
47	Hemorphin-4 (H-4) (Human, Bovine)	050-09	565.26
48	TIPP / delta-Opioid Antagonist	050-22	634.73
49	[Tyr0, Trp2]-Melanocyte Inhibiting Factor 1 (MIF-1)	050-23	520.57
50	[Tyr0]-Melanocyte Inhibiting Factor 1 (MIF-1)	050-24	447.51
51	Casomorphin (1-5), beta	044-03	579.28
52	acetyl-Endorphin, beta (1-26) (Human)	022-11	2899.53
53	Endorphin, beta (Human)	022-14	3465.53
54	Endorphin, beta (2-31) (Human)	022-15	3301.86
55	Endorphin, beta (1-26) (Human)	022-27	2857.51
56	Endorphin, beta (1-27) (Human)	022-28	3020.58
57	Endorphin, beta (Rat)	022-33	3466.07
58	Endorphin, gamma / Lipotropin, beta (61-77) (Human, Bovine, Ovine, Camel)	022-36	1857.93

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Our Cancer and Immunomodulatory Peptide Libraries allow for hundreds of cancer-related peptides to be analyzed in parallel. This can drastically reduce the time needed for your drug discovery, ligand-binding, or antibody development efforts.

The effects of programmed cell death 1 (PD-1)−programmed death 1/2 ligand (PD-L1/2) interaction on T cells. PD-L1/2 is expressed by tumor cells and antigen-presenting cells (APCs). In tumor cells, PD-L1 expression may be induced by interaction between IFN-γ and IFN-γ receptor (IFN-γ R), activation of epidermal growth factor receptor (EGFR), mitogen-activated protein kinase (MAPK), and/or PI3K-Akt signaling pathways, and upregulation of signal transducer and activator of transcription 3 (STAT3) or hypoxia induced factor 1 (HIF-1). Then, interaction of PD-1 with PD-L1 can activate Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2) and inhibit activation of T cell receptor (TCR)/major histocompatibility complex (MHC)-triggered NF-κB, PI3K, or other signaling pathways, leading to increased apoptosis and impaired T cell function, migration, and proliferation.

Figure from: Song M et. Al. Future of anti-PD-1/PD-L1 applications: Combinations with other therapeutic regimens. Chin J Cancer Res. 2018 Apr; 30(2): 157–172. doi: 10.21147/j.issn.1000-9604.2018.02.01

T cell inhibitory receptor PD-1 expressed on tumor cells and tumor-infiltrating APCs neutralizes its ligand, PD-L1, in cis to inhibit canonical PD-1 signaling.

The interaction between PD-1 on T cells and its ligand PD-L1, which is highly expressed on several types of human tumor cells and tumor infiltrating immune cells, restrains the activity of effector T cells against human cancers and chronic virus infections.

Zhao et al. (Cell Rep. 2018 Jul 10;24(2):379-390) show that the T cell inhibitory receptor PD-1 expressed on tumor cells and tumor-infiltrating APCs neutralizes its ligand, PD-L1, in cis to inhibit canonical PD-1 signaling. Selective blockade of tumor-intrinsic PD-1 frees up tumor PDL1 for T cell suppression. Peptide/protein that block PD-L1/PD-1 interactions have produced durable clinical benefits.

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