SARS-COV-2 S Protein Fingerprint Peptide Library

	Catalog #	Size	Price
	L-017	53 peptides	$9577

Contents:

96 well plate(s), where each well contains 100ug of NET peptide.
(Please inquire for larger peptide quantity)

	Peptide Name	Catalog No.	MW
1	SARS-COV-2 S Protein (238 - 246)	074-51	1098.32
2	SARS-COV-2 S Protein (635 - 646)	074-52	1358.49
3	SARS-COV-2 S Protein (948 - 964)	074-53	1868.14
4	SARS-COV-2 S Protein (559 - 567)	074-54	1139.33
5	SARS-COV-2 S Protein (103 - 113)	074-55	1224.39
6	SARS-COV-2 S Protein (766 - 786)	074-56	2289.54
7	SARS-COV-2 S Protein (347 - 355)	074-57	1113.25
8	SARS-COV-2 S Protein (1001 - 1014)	074-58	1690.98
9	SARS-COV-2 S Protein (78 - 97)	074-59	2316.52
10	SARS-COV-2 S Protein (766 - 776)	074-60	1144.30
11	SARS-COV-2 S Protein (568 - 577)	074-61	1076.12
12	SARS-COV-2 S Protein (906 - 921)	074-62	1824.04
13	SARS-COV-2 S Protein (311 - 319)	074-63	1085.20
14	SARS-COV-2 S Protein (934 - 947)	074-64	1377.53
15	SARS-COV-2 S Protein (922 - 933)	074-65	1275.48
16	SARS-COV-2 S Protein (196 - 202)	074-66	855.93
17	SARS-COV-2 S Protein (777 - 786)	074-67	1163.31
18	SARS-COV-2 S Protein (151 - 158)	074-68	1071.79
19	SARS-COV-2 S Protein (247 - 273)	074-69	2839.09
20	SARS-COV-2 S Protein (445 - 464)	074-70	1218.35
21	SARS-COV-2 S Protein (320 - 328)	074-71	1028.16
22	SARS-COV-2 S Protein (826 - 835)	074-72	1034.23
23	SARS-COV-2 S Protein (1206 - 1211)	074-73	843.96
24	SARS-COV-2 S Protein (409 - 417)	074-74	899.02
25	SARS-COV-2 S Protein (311 - 319)	074-75	1085.20
26	SARS-COV-2 S Protein (30 - 41)	074-76	1445.69
27	SARS-COV-2 S Protein (558 - 567)	074-77	1267.51
28	SARS-COV-2 S Protein (836 - 847)	074-78	1281.39
29	SARS-COV-2 S Protein (387 - 403)	074-79	1989.97
30	SARS-COV-2 S Protein (404 - 417)	074-80	1455.60
31	SARS-COV-2 S Protein (159 - 182)	074-81	2743.09
32	SARS-COV-2 S Protein (329 - 346)	074-82	2040.35
33	SARS-COV-2 S Protein (531 - 537)	074-83	903.04
34	SARS-COV-2 S Protein (922 - 933)	074-84	1275.48
35	SARS-COV-2 S Protein (207 - 216)	074-85	949.13
36	SARS-COV-2 S Protein (816 - 835)	074-86	2241.63
37	SARS-COV-2 S Protein (1020 - 1028)	074-87	845.96
38	SARS-COV-2 S Protein (1039 - 1045)	074-88	823.98
39	SARS-Cov-2 S Protein (455-509)	071-68	6285.05
40	SARS-CoV-2 S Protein (437-485)	071-70	5531.13
41	SARS-Cov-2 S Protein (1092-1157)	071-62	7260.30
42	SARS-Cov-2 S Protein (1040 - 1091)	071-60	5755.00
43	SARS-CoV-2 S Protein (437-509)	071-75	8358.00
44	SARS-Cov-2 S Protein (444-494)	071-72	5884.89
45	SARS-COV-2 S Protein (672-692)	074-92	2347.17
46	2019-nCov Spike Protein (984-1037)	074-58	5931.70
47	2019-nCov-HR1P	074-54	4386.89
48	2019-nCov-HR2P	074-56	4008.50
49	EK1 / Pan-HCoV S Inhibitor	071-52	4332.03
50	Mono-Cy5-2019-nCov-HR2P	FC5-071-56	4649.50
51	SARS-COV-2 S Protein (500-505) /wtAIDS	074-90	609.64
52	SARS-COV-2 S Protein (500-505) / N501Y-AIDS	074-91	658.72
53	DX 600/ ACE2-Specific Peptide Inhibitor	002-26	3076.38

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Our Cancer and Immunomodulatory Peptide Libraries allow for hundreds of cancer-related peptides to be analyzed in parallel. This can drastically reduce the time needed for your drug discovery, ligand-binding, or antibody development efforts.

The effects of programmed cell death 1 (PD-1)−programmed death 1/2 ligand (PD-L1/2) interaction on T cells. PD-L1/2 is expressed by tumor cells and antigen-presenting cells (APCs). In tumor cells, PD-L1 expression may be induced by interaction between IFN-γ and IFN-γ receptor (IFN-γ R), activation of epidermal growth factor receptor (EGFR), mitogen-activated protein kinase (MAPK), and/or PI3K-Akt signaling pathways, and upregulation of signal transducer and activator of transcription 3 (STAT3) or hypoxia induced factor 1 (HIF-1). Then, interaction of PD-1 with PD-L1 can activate Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2) and inhibit activation of T cell receptor (TCR)/major histocompatibility complex (MHC)-triggered NF-κB, PI3K, or other signaling pathways, leading to increased apoptosis and impaired T cell function, migration, and proliferation.

Figure from: Song M et. Al. Future of anti-PD-1/PD-L1 applications: Combinations with other therapeutic regimens. Chin J Cancer Res. 2018 Apr; 30(2): 157–172. doi: 10.21147/j.issn.1000-9604.2018.02.01

T cell inhibitory receptor PD-1 expressed on tumor cells and tumor-infiltrating APCs neutralizes its ligand, PD-L1, in cis to inhibit canonical PD-1 signaling.

The interaction between PD-1 on T cells and its ligand PD-L1, which is highly expressed on several types of human tumor cells and tumor infiltrating immune cells, restrains the activity of effector T cells against human cancers and chronic virus infections.

Zhao et al. (Cell Rep. 2018 Jul 10;24(2):379-390) show that the T cell inhibitory receptor PD-1 expressed on tumor cells and tumor-infiltrating APCs neutralizes its ligand, PD-L1, in cis to inhibit canonical PD-1 signaling. Selective blockade of tumor-intrinsic PD-1 frees up tumor PDL1 for T cell suppression. Peptide/protein that block PD-L1/PD-1 interactions have produced durable clinical benefits.

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