Obesity Peptide Library

	Catalog #	Size	Price
	L-003	160 peptides	$6864

Contents:	96 well plate(s), where each well contains 1.5 nmol of peptide packaged in 15µg of BSA. (Please inquire for larger peptide quantity)
List of Peptides:	Download(PDF)

	ACTH (Human)	Catelog No.	M.W.
1	ACTH (Human)	001-01	4524.21
2	ACTH (1-24) (Human, Rat, Mouse, Porcine)	001-06	2933.48
3	Corticotropin Like Intermediate Lobe Peptide (CLIP) / ACTH 18-39 (Human)	001-14	2465.70
4	Prepro-In1-Ghrelin (24-117) (Human)	032-49	10699.15
5	Leptin (57-92) (Human)	003-02	3985.73
6	Leptin (22-56) (Human)	003-06	3950.55
7	Leptin (Human)	003-12	~16k
8	Leptin (Mouse)	003-13	~16k
9	Orexin A (Human, Rat, Mouse, Porcine, Ovine, Bovine)	003-30	3561.16
10	Orexin B (Human)	003-31	2899.37
11	Orexin B (Rat, Mouse)	003-32	2936.44
12	Orexin B (3-28) (Rat, Mouse)	003-33	2683.14
13	Orexin A (16-33) (Human, Rat, Mouse, Porcine, Ovine)	003-36	1862.16
14	GIP (1-30) Amide (Human)	027-30	3530.99
15	Hypocretin-1-Gly (Rat, Mouse)	003-40	4091.75
16	Hypocretin-2-Gly (Human)	003-41	2957.41
17	Agouti (1-40)-NH2 (Human)	003-50	4483.15
18	Agouti-Related Protein (25-51) (Human)	003-51	2894.50
19	Agouti-Related Protein (54-82) (Human)	003-52	3282.50
20	Agouti-Related Protein (83-132)-NH2 (Human)	003-53	5676.66
21	Agouti Signalling Protein (ASP) (87-132)-NH2 (Human)	003-54	4828.70
22	Agouti-Related Protein (AGRP) (71-132) Form C-NH2 (Human)	003-55	7028.14
23	CART (55-102) (Human)	003-60	5243.21
24	CART (61-102) (Human, Rat, Mouse, Bovine)	003-61	4513.34
25	Neuromedin N (Porcine)	046-38	745.48
26	Galanin-Like Peptide (GALP) (Human)	026-51	6500.37
27	Neurotensin (8-13) (Human)	048-09	816.51
28	Xenin (18-25) / Xenin-8 (Human)	046-95	1046.28
29	Mahogany (1377-1428) (Mouse)	003-87	2923.56
30	MSH, Alpha (Human, Rat, Mouse)	043-01	5312.17
31	MSH, Beta (Human)	043-12	2660.95
32	MSH, Gamma (Human, Rat, Mouse)	043-16	1570.80
33	MSH, Gamma1 (Human, Rat, Mouse)	043-17	1511.71
34	MSH, Lys-Gamma1 (Human, Rat, Mouse)	043-18	1639.80
35	MSH, Gamma3 (Human)	043-19	2943.22
36	MSH-Releasing Inhibiting Factor (MIF) (Multiple)	043-20	284.17
37	MT II (Multiple)	043-23	1024.20
38	SHU 9119 (Multiple)	043-24	1075.30
39	MSH, beta (11-22) Cyclic-[Ac-Cys11, D-Nal14, Cys18, Asp22] / HS 014 (Multiple)	043-25	1564.80
40	MSH, Alpha (3-11) Cyclic-[Ac-Cys3, Nle4, Arg5, D-Nal7-Cys11] / HS 024 (Multiple)	043-27	1267.53
41	JKC-363 (cyclic[Mpr11, D-Nal14, Cys18, Asp22]-Beta-MSH (11-22) Amide (Multiple)	043-26	1506.80
42	JKC-366 (cyclic[Mpr3, Nle4, Arg5, D-Nal7, Cys11]-Alpha-MSH (3-11) Amide (Multiple)	043-28	1231.53
43	Neuropeptide Y (NPY) (Human, Rat, Mouse)	049-03	4272.73
44	Neuropeptide Y (NPY) (3-36) (Porcine)	049-20	3990.99
45	Neuropeptide Y (NPY), [Leu31,Pro34] (Porcine)	049-08	4220.10
46	Neuropeptide Y (NPY) (2-36) (Porcine)	049-09	4088.04
47	Neuropeptide Y (NPY) (13-36) (Porcine)	049-10	2980.56
48	Neuropeptide Y (NPY), [D-Trp32] (Porcine)	049-19	4338.82
49	Galanin (Human)	026-01	3157.45
50	Galanin (1-16) (Rat, Porcine)	026-08	1668.87
51	Galanin (65-105)-NH2, Prepro (Porcine)	026-09	4640.35
52	Galanin (Rat)	026-13	3164.49
53	Galantide (Multiple)	026-15	2198.08
54	Galanin (1-13)-Bradykinin (2-9) Amide (M35) (Multiple)	026-16	2233.55
55	Proopiomelanocortin Precursor (POMC) (27-52) (Porcine)	029-30	2895.31
56	MGOP-14 (Human)	035-50	1786.26
57	MGOP-27 (Human)	035-51	3284.90
58	NEI (Neuropeptide EI) (Human, Rat, Mouse)	070-49	1447.56
59	NGE (Neuropeptide GE) (Mouse)	070-51	1932.98
60	Melanin-Concentrating Hormone (MCH) (Human, Rat, Mouse)	070-47	2386.88
61	Melanin-Concentrating Hormone (MCH) [Phe13, Tyr19] (Human, Rat, Mouse)	070-45	2436.94
62	Beacon (30-73) (Posammomys obesus)	072-51	5273.06
63	Bombesin (Bombina bombina)	007-01	1620.87
64	Corticotropin Releasing Factor (CRF) (Human, Rat, Mouse, Canine, Feline)	019-06	4757.52
65	Exendin-3 (Heloderma horridum)	070-92	4200.01
66	Exendin-4 (Heloderma suspectum)	070-94	4184.01
67	Ghrelin (Human)	031-30	3371.92
68	Ghrelin (Rat, Mouse)	031-31	3314.00
69	Galanin-like Peptide (GALP) (Rat)	026-52	6502.43
70	Glucagon (72-108) Prepro / Glucagon-Like Peptide-1 (GLP-1) (Human, Rat, Mouse, Porcine, Bovine, Ovine)	028-09	4167.02
71	Oxyntomodulin (Human, Rat, Mouse)	028-22	4449.90
72	HMGIC (48-109)-NH2 (Human)	004-11	6940.68
73	Motilin (Human, Porcine)	045-03	2697.38
74	Prolactin-Releasing Peptide-31 (PrRP-31) (Human)	008-50	3664.18
75	Prolactin-Releasing Peptide-20 (PrRP-20) (Human)	008-51	2273.60
76	Prolactin-Releasing Peptide-31 (PrRP-31) (Rat)	008-52	3594.04
77	Prolactin-Releasing Peptide-20 (PrRP-20) (Rat)	008-53	2529.90
78	Neuromedin U-9 (Mouse, Guinea Pig)	046-37	1168.37
79	Neuromedin U-23 (Mouse)	046-65	2706.06
80	Neuromedin U-25 (Human)	046-42	3080.42
81	Neuromedin U (Rat)	046-41	2641.34
82	Neuromedin U-8 (Porcine)	046-39	1110.59
83	Neuropeptide AF (huNPAF) (Human)	048-40	1978.18
84	Neuropeptide FF (huNPFF, NPSF) (Human)	048-41	1367.57
85	Urocortin (Human)	019-14	4696.31
86	Urocortin (Rat)	019-15	4707.33
87	Urocortin II (Mouse)	019-24	4152.59
88	Neuropeptide W-23 (NPW-23) (Human)	005-60	2584.05
89	Neuromedin S (17-33) (Human)	045-84	2117.39
90	Neuromedin S (20-36) (Rat, Mouse)	045-85	2020.31
91	Neuromedin S Amide (Human)	045-86	3792.35
92	Neuromedin S (Mouse)	045-88	4259.06
93	Neuropeptide S (Human)	005-89	2187.51
94	Adropin (34-76) (Human)	032-35	4499.90
95	Alarin (6-25) (Human)	026-31	2361.69
96	Alarin (Human)	026-34	2894.29
97	Alarin (Mouse)	026-32	2786.15
98	Alarin (Rat)	026-33	2820.17
99	Adipocyte fatty Acid Binding Protein / A-FABP(110-132) (Human)	006-12	2628.02
100	Amylin Amide /IAPP (Human)	017-04	3900.84
101	Amylin (Rat, Mouse)	017-11	3920.45
102	Bomebesin Receptor Subtype-2 (BRS-3) Agonist (Bombina bombina)	007-14	496.63
103	Bombesin (6-14) [D-Tyr6, (R)-Apa11, 4-Cl-Phe13, Nle14] (Bombina bombina)	007-15	1245.64
104	Bombesin (6-14) [D-Tyr6,(S)-Apa11, 4-Cl-Phe13, Nle14] (Bombina bombina)	007-16	1245.64
105	Bombesin (6-14) [D-Tyr6, Des-Met14] Ethylamide (Bombina bombina)	007-07	983.55
106	Hypothetical Protein XP_294524 (171-196) Amide / P518 / QRFP-26] (Human)	048-76	2832.16
107	Pro-SAAS (245-260) / Big-LEN (Human)	004-53	1755.09
108	Pro-SAAS (221-242) / PEN (Human)	004-52	2215.49
109	MCH (6-16)-NH2 [Ac-D-Arg6, Asn10] / MC-1 Agonist (Human)	070-82	1452.77
110	Galanin (1-30), Prepro (Human)	026-03	2938.64
111	Galanin (2-11) Amide (Human)	026-21	1136.32
112	Galanin (65-88), Prepro (Human)	026-04	2845.36
113	Galanin (89-123) (Human)	026-05	3840.04
114	GHRP-6 /GHRP [His1,Lys6] (Multiple)	031-21	872.43
115	Ghrelin (86-117), Prepro (Rat)	031-36	3626.09
116	GLP-1[Ac]-(7-36) Amide (Human, Rat, Mouse, Porcine, Bovine, Ovine)	028-24	3338.65
117	GLP-1 (7-37) (Human, Rat, Mouse, Porcine, Bovine, Ovine)	028-13	3355.71
118	GLP-1 (28-36) Amide (Human, Rat, Mouse, Porcine, Bovine, Ovine)	028-73	1088.35
119	GLP-1 (32-36) Amide (Human, Rat, Mouse, Porcine, Bovine, Ovine)	028-74	570.72
120	GLP-1 (28-37) (Human, Rat, Mouse, Porcine, Bovine, Ovine)	028-75	1146.40
121	INSL5 (Mouse)	035-40	5117.04
122	INSL5 (Short A- & B-Chains) (Human)	035-70	5048.00
123	INSL5 C peptide, Prepro (49-114) (Mouse)	035-87	7691.61
124	Relaxin 3 / RLF (Human)	035-27	6292.32
125	R3 (BDelta23-27) R / I5 Chimeric Peptide (Human)	035-66	4853.70
126	Nesfatin-1 (30-59) (Rat, Mouse)	009-75	3692.14
127	Nesfatin-1 (1-29) (Mouse)	009-76	3247.61
128	Nesfatin-1 (60-82) (Rat, Mouse)	009-77	2708.07
129	Neuromedin U, Prepro (104-136) (Human)	045-96	3782.45
130	Nasfatin-1 (1-82) (Rat)	003-22	9582.80
131	Nesfatin-1 (1-45) / Nestatin-1 N-terminal (Human)	003-24	5170.80
132	Nesfatin-1 (1-82) (Human)	003-26	9551.86
133	PYY (3-36) (Human)	059-02	4049.71
134	TLQP-21 Amide (Human)	007-85	2490.86
135	TLQP-21 (Rat, Mouse)	003-89	2432.78
136	Urotensin II (Human)	071-05	1388.56
137	Urotensin II (Mouse)	071-08	1633.86
138	NERP-1 / VGF, Prepro (281-306) (Human)	076-89	2678.99
139	NERP-2 / VGF, Prepro (310-347) (Human)	076-91	4064.55
140	AQEE-19 / VGF, Prepro (597-615) (Human)	007-73	2408.70
141	AQEE-30 / VGF, Prepro (586-615) (Human)	007-70	3705.83
142	VGF, Prepro(427-436)(Rat) (Rat)	007-78	1136.24
143	Alamandin / Angiotensin A (1-7) (Human, Rat, Mouse, Canine)	002-10	855.00
144	Angiortensin I (1-7) / Angiotensin II (1-7) (Human, Rat, Mouse, Canine)	002-24	899.02
145	KiSS-1 (112-121) Amide / Kisspeptin-10 / Metastin (45-54) Amide (Human)	048-56	1302.44
146	GPR-54 agonist / Peptide 34 (Multiple)	048-94	858.11
147	Kisspeptin Antagonist / p234 (Multiple)	048-95	1294.42
148	Kisspeptin Antagonist / p234 penetratin (Multiple)	048-96	2429.87
149	Pancrerastatin / Chromogranin A (250-301) Amide (Human)	053-05	5505.54
150	Pancrerastatin(24-52) /h PST29 (Human)	053-06	3280.53
151	Alpha-7-Nicotinic Acetylcholine receptor Ligand / nAChR (Multiple)	075-12	1864.12
152	Obestatin (Rat, Mouse)	031-90	2516.85
153	Obestatin (Human, Monkey)	031-92	2546.87
154	Obestatin-Gly (Rat, Mouse)	031-93	2574.91
155	Ghrelin [Ser3(Des-Octanoyl)] (Human)	031-32	3244.71
156	Dap3 (Octanyol)-Ghrelin (Human)	031-58	3369.92
157	Ghrelin (1-5) [Dap3-Ocatnoyl] Amide (Human, Rat, Mouse)	032-14	631.72
158	Ghrelin (1-5) Amide (Human, Rat, Mouse, Bovine, Canine)	031-41	634.56
159	Neuronostatin-13 (Human) (Human, Porcine)	060-50	1415.67
160	Neuronostatin-13 (Rat, Mouse) (Rat, Mouse)	060-48	1445.70

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Our Cancer and Immunomodulatory Peptide Libraries allow for hundreds of cancer-related peptides to be analyzed in parallel. This can drastically reduce the time needed for your drug discovery, ligand-binding, or antibody development efforts.

The effects of programmed cell death 1 (PD-1)−programmed death 1/2 ligand (PD-L1/2) interaction on T cells. PD-L1/2 is expressed by tumor cells and antigen-presenting cells (APCs). In tumor cells, PD-L1 expression may be induced by interaction between IFN-γ and IFN-γ receptor (IFN-γ R), activation of epidermal growth factor receptor (EGFR), mitogen-activated protein kinase (MAPK), and/or PI3K-Akt signaling pathways, and upregulation of signal transducer and activator of transcription 3 (STAT3) or hypoxia induced factor 1 (HIF-1). Then, interaction of PD-1 with PD-L1 can activate Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2) and inhibit activation of T cell receptor (TCR)/major histocompatibility complex (MHC)-triggered NF-κB, PI3K, or other signaling pathways, leading to increased apoptosis and impaired T cell function, migration, and proliferation.

Figure from: Song M et. Al. Future of anti-PD-1/PD-L1 applications: Combinations with other therapeutic regimens. Chin J Cancer Res. 2018 Apr; 30(2): 157–172. doi: 10.21147/j.issn.1000-9604.2018.02.01

T cell inhibitory receptor PD-1 expressed on tumor cells and tumor-infiltrating APCs neutralizes its ligand, PD-L1, in cis to inhibit canonical PD-1 signaling.

The interaction between PD-1 on T cells and its ligand PD-L1, which is highly expressed on several types of human tumor cells and tumor infiltrating immune cells, restrains the activity of effector T cells against human cancers and chronic virus infections.

Zhao et al. (Cell Rep. 2018 Jul 10;24(2):379-390) show that the T cell inhibitory receptor PD-1 expressed on tumor cells and tumor-infiltrating APCs neutralizes its ligand, PD-L1, in cis to inhibit canonical PD-1 signaling. Selective blockade of tumor-intrinsic PD-1 frees up tumor PDL1 for T cell suppression. Peptide/protein that block PD-L1/PD-1 interactions have produced durable clinical benefits.

Identification of receptors for neuromedin U and its role in feeding.

Howard AD, Wang R, Pong SS, et al. Nature. 2000;406(6791):70-4.

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